1. American Diabetes Association (2005) Diagnosis and classification of diabetes mellitus. Diabetes Care 28: S37-S42. 2. Aguirre H, Báez B, Soto M, Galindo R y Wacher N (2000) Demanda de atención médica en el IMSS por derechohabientes de 65 años y mayores. Análisis epidemiológico. Rev Med IMSS 38: 39–52. 3. Cardon L R y Bell J I (2001) Association study designs for complex disease. Nat Rev Genet 2: 91–99. 4. Florez J C, Hirschhorn J y Altshuler D (2003) The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 4: 257-291. 5. Horikawa Y, Oda N, Cox N J, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner T H, Mashima H, Schwarz P E, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky K S, Wei S, Concannon P, Iwasaki N, Schulze J, Baier L J, Bogardus C, Groop L, Boerwinkle E, Hanis CL y Bell G I (2000) Genetic variation in the geneencoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26: 163-175. 6. Horikawa Y, Oda N, Yu L, Imamura S, Fujiwara K, Makino M, Seino Y, Itoh M y Takeda J (2003) Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in japanese. J Clin Endocrinol Metab 88: 244-247. 7. Kersten S, Desvergne B y Wahli W (2000) Roles of PPARs in health and disease. Nature 405: 421– 424. 8. Doney A, Fischer B, Frew D, Cumming A, Flavell D M, World M, Montgomery H E, Boyle D, Morris A y Palmer C N (2002) Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight. BMC Genet 13: 3-21. 9. Attie A D y Kendziorki, C M (2003) PGC-1alpha at the crossroads of type 2 diabetes. Nat Genet 34: 244-245. 10. Sesti G, Cardellini M, Marini MA, Frontoni S, D’Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P y Lauro R. (2003) A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose–tolerant subjects. Diabetes 52: 1280–1283. 11. Marini M A, Frontoni S, Mineo D, Bracaglia D, Cardellini M, De Nicolais P, Baroni A, D’Alfonso R, Perna M, Lauro D, Federici M, Gambardella S, Lauro R y Sesti G (2003) The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. J Clin Endocrinol Metab 88: 3368-3371. 12. Esposito D L, Li Y, Vanni C, Mammarella S, Veschi S, Della Loggia F, Mariani-Costantini R, Battista P, Quon M J y Cama A (2003) A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. J Clin Endocrinol Metab 88: 1468-1475. 13. Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft F M y Laakso M (2003) A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet 361: 301–307. 14. Korbonits M, Gueorguiev M, O’Grady E, Lecoeur C, Swan D C, Mein CA, Weill J, Grossman A B y Froguel P (2002) A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab. 87: 4005-4008. 15. Wong G W, Wang J, Hug C, Tsao T S y Lodish H F (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A. 101: 10302-10307.
1. American Diabetes Association (2005) Diagnosis and classification of diabetes mellitus. Diabetes Care 28: S37-S42.
2. Aguirre H, Báez B, Soto M, Galindo R y Wacher N (2000) Demanda de atención médica en el IMSS por derechohabientes de 65 años y mayores. Análisis epidemiológico. Rev Med IMSS 38: 39–52.
3. Cardon L R y Bell J I (2001) Association study designs for complex disease. Nat Rev Genet 2: 91–99.
4. Florez J C, Hirschhorn J y Altshuler D (2003) The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits. Annu Rev Genomics Hum Genet 4: 257-291.
5. Horikawa Y, Oda N, Cox N J, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner T H, Mashima H, Schwarz P E, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky K S, Wei S, Concannon P, Iwasaki N, Schulze J, Baier L J, Bogardus C, Groop L, Boerwinkle E, Hanis CL y Bell G I (2000) Genetic variation in the geneencoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26: 163-175.
6. Horikawa Y, Oda N, Yu L, Imamura S, Fujiwara K, Makino M, Seino Y, Itoh M y Takeda J (2003) Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in japanese. J Clin Endocrinol Metab 88: 244-247.
7. Kersten S, Desvergne B y Wahli W (2000) Roles of PPARs in health and disease. Nature 405: 421– 424.
8. Doney A, Fischer B, Frew D, Cumming A, Flavell D M, World M, Montgomery H E, Boyle D, Morris A y Palmer C N (2002) Haplotype analysis of the PPARgamma Pro12Ala and C1431T variants reveals opposing associations with body weight. BMC Genet 13: 3-21.
9. Attie A D y Kendziorki, C M (2003) PGC-1alpha at the crossroads of type 2 diabetes. Nat Genet 34: 244-245.
10. Sesti G, Cardellini M, Marini MA, Frontoni S, D’Adamo M, Del Guerra S, Lauro D, De Nicolais P, Sbraccia P, Del Prato S, Gambardella S, Federici M, Marchetti P y Lauro R. (2003) A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose–tolerant subjects. Diabetes 52: 1280–1283.
11. Marini M A, Frontoni S, Mineo D, Bracaglia D, Cardellini M, De Nicolais P, Baroni A, D’Alfonso R, Perna M, Lauro D, Federici M, Gambardella S, Lauro R y Sesti G (2003) The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients. J Clin Endocrinol Metab 88: 3368-3371.
12. Esposito D L, Li Y, Vanni C, Mammarella S, Veschi S, Della Loggia F, Mariani-Costantini R, Battista P, Quon M J y Cama A (2003) A novel T608R missense mutation in insulin receptor substrate-1 identified in a subject with type 2 diabetes impairs metabolic insulin signaling. J Clin Endocrinol Metab 88: 1468-1475.
13. Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft F M y Laakso M (2003) A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1. Lancet 361: 301–307.
14. Korbonits M, Gueorguiev M, O’Grady E, Lecoeur C, Swan D C, Mein CA, Weill J, Grossman A B y Froguel P (2002) A variation in the ghrelin gene increases weight and decreases insulin secretion in tall, obese children. J Clin Endocrinol Metab. 87: 4005-4008.
15. Wong G W, Wang J, Hug C, Tsao T S y Lodish H F (2004) A family of Acrp30/adiponectin structural and functional paralogs. Proc Natl Acad Sci U S A. 101: 10302-10307.